© Courtney Hunt, MD, 2026 Modern medicine organizes disease into silos. Cardiology treats the heart. Endocrinology treats hormones. Neurology treats the brain. Oncology treats cancer. Reproductive medicine treats fertility. Biology does not operate in silos. Across nearly every chronic disease, the same metabolic disturbance appears years before diagnosis. That disturbance is insulin resistance. Insulin resistance is not simply a blood sugar problem. It represents a breakdown

© Courtney Hunt, MD, 2026 The kidney is among the most metabolically demanding organs in human physiology. Each day it filters approximately 180 liters of plasma, reclaiming electrolytes, glucose, amino acids, and water through tightly regulated transport processes occurring primarily in the proximal tubule. These processes are driven by dense mitochondrial populations that generate ATP required for ion transport and solute reabsorption. Consequently, renal physiology is fund

Modern medicine has normalized a metabolic state that human physiology was never designed to sustain. The constant dependence on carbohydrates as a primary fuel source is a recent phenomenon in evolutionary time. For the majority of human history, metabolic flexibility—particularly the ability to burn fat and generate ketones—was not an optional adaptation. It was the default. The human organism evolved under conditions of intermittent food availability, seasonal carbohydrate

© Courtney Hunt, MD, 2026 Multicellular life requires coordination. Every cell in the human body operates inside a regulated system that integrates metabolism, electrical gradients, mitochondrial function, and tissue-level growth control. These systems allow trillions of cells to function as a single organism. Cancer develops when a cell loses integration with this system. At its core, cancer is not simply uncontrolled growth. It is a failure of cellular communication, where